Bisphosphonates adverse event rate differences

2019-03-14

Rate in treatment arm minus rate in control arm.

Including only studies with a placebo or other non-biphosphonate control.

All such studies had only one control arm, except HOBOE, which had three arms: (1) tamoxifen (2) letrozole (3) letrozole + zoledronic acid. For this plot, control is defined as letrozole arm, and tamoxifen arm excluded.

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'

## Warning in dev_fun(file = tempfile(), width = width %||% 640, height =
## height %||% : partial argument match of 'file' to 'filename'